May be associated with uterine lymphoepitheliomalike carcinoma metastases common to regional lymph nodes. Multidisciplinary therapy was usually required to achieve longterm survival. More recently, dog1 expression has been reported in salivary gland tumours 68, in particular, as a marker for acinic and intercalated duct cells. Judiciously applied, fnab can assist the clinician in developing a suitable treatment plan. Evaluation of cystic salivary gland lesions by fineneedle aspiration. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. These glands have an important role in aliments digestion through their secretions saliva.
You will find a list of common subtypes of salivary gland tumors. In these populations, it is usually associated with epsteinbarr virus. Parotid lesions never cause facial nerve dysfunction or cervical lymphadenopathy, and those of the palate rarely ulcerate. Myoepitheliomas are most common in young adults between the ages of 30 and 50. Also most of the parotid benign tumors are located on the superficial lobe. Twelve of these were located within the parotid gland and the submandibular gland and intraoral minor salivary glands accounted for five each. Pleomorphic adenoma a salivary gland tumor as nasal mass. Capsules are generally better developed in tumors of the major glands, whereas those arising in the palate or other minor salivary or seromucinous gland sites are circumscribed but not usually encapsulated. A myoepithelioma neoplasm is almost entirely composed of myoepithelial cells and is most frequently located in the parotid gland and in the minor salivary glands of the hard palate. Tumors of minor salivary glands e583 introduction salivary gland neoplasms represent less than 1% of all tumors, and 35% of all head and neck neoplasms.
Only 1% of all salivary gland neoplasms are myoepitheliomas. Classification of the pathology of diseases of the salivary glands. The histological appearance includes solid, myxoid and reticular growth patterns. Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. This report summarizes the experience with tumors of salivarygland origin observed at the massachusetts general hospital from 1930 to 1941, inclusive. Your doctor can provide more information about your specific diagnosis. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement. Tumors of the salivary glands exhibit a wide variety of behavior and are widely diversified histologically. Sep 10, 2018 epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. If you continue browsing the site, you agree to the use of cookies on this website. Sialoliths are hard formations, with round or oval shape and a variety of sizes. A comparative study of mucin histochemistry in mucous cells of salivary glands and odontogenic cysts ridwaana carim a research report submitted to the faculty of health sciences, school of oral health sciences, university of witwatersrand, south africa, in partial fulfilment of the requirements for the degree of. Clear cell carcinoma of minor salivary gland case report. Among these 8590% originates from the major salivary glands.
Lung carcinomas of the salivary gland type are also known as salivary glandtype tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5. Lymphoepitheliallike carcinoma of the parotid gland. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Physiology, pathology and regeneration of salivary glands mdpi. The signs and symptoms of myoepithelioma of salivary gland may include. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary glands of the oral cavity. Salivary glands primary salivary gland neoplasms malignant lymphoepithelial carcinoma. Parotid small cell carcinoma presenting with longterm. Most 70% salivary gland tumors originate in the parotid gland, with the bulk of the remainder arising in the submandibular gland 8% and in the minor salivary glands 22%.
Clinically, an etiological classification of sialadenitis is mandatory. Salivary gland, sublingual, duct hyperplasia in a male f344n rat from a chronic study higher magnification of figure 5. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. It can be present in individuals of a wide age range including children and adults. Gonsai3 1resident, 2additional professor, 3professor and head, department of pathology, b.
Tumors of the salivary glands exhibit a wide variety of. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. As reaffirmed in our case, lec is more common in women, occurs primarily in the parotid gland, and has an ethnic predilection. Discussion salivary gland tumors are complex neoplasms which account for 3% of all head and neck tumours. Plasmacytoid myoepithelioma of minor salivary glands. Nov 17, 2014 salivary gland, sublingual, duct hyperplasia in a male f344n rat from a chronic study higher magnification of figure 5. Myoepithelioma is a wellcircumscribed or encapsulated tumor. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the. Myoepithelioma, salivary glands, mouse springerlink. Humans have three paired major salivary glands parotid. A case report of coexistence of a sialolith and an adenoid cystic. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. An lec of the parotid is a rare salivary gland tumor accounting for less than 1% of all salivary gland tumors.
However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Salivary gland myoepithelioma with focal capsular invasion. Although clear cells are found in a number of salivary gland tumours, most can be excluded based on other typical cellular or growth phenotypes. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Developmental changes in the parotid salivary gland of. Histopathological study of salivary gland tumors 88 int j res med. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. It is observed in a wide age category of children and adults. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor. This customization is achieved in accordance with existing clinical standards to guarantee a reliable and safe solution. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues.
Losito nsbotti gionna fpasquinelli gminenna pbisceglia m clearcell myoepithelial carcinoma of the salivary glands. Epithelialmyoepithelial carcinoma of salivary gland. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. We represent basal cell adenoma of the parotid gland which was located on the deep lobe of the gland with unusual location the. Lung carcinomas of the salivary gland type radiology. Salivary gland tumours are rare and most cases are referred to the head and neck clinic.
It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. The sublingual gland is the smallest of the three major salivary glands, which also include the parotid and submandibular glands. Primary lymphoepitheliallike carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. As the name suggests, it consists of myoepithelial cells. Myoepitheliomas usually occur in the major salivary glands and appear in the subcutis of the ventral neck. Pleomorphic adenoma is the most common benign salivary gland tumor. Review of the major and minor salivary glands, part 1. Lung carcinomas of the salivary gland type are also known as salivary glandtype tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5 epidemiology. The salivary glands are classified as major or minor. Pdf spindle cell myoepithelioma of the parotid gland. The abundant serous exocrine cells make up the bulk of the gland. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign. The parotid salivary gland being one of the major salivary glands of. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells.
They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%. Parotid gland the parotid gland is composed mainly of serous cells and produces saliva that is watery and rich in enzymes amylase and lysozyme and antibodies. Additionally, ser156 phosphorylation may be important for cancer development. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Lymphoepitheliomalike carcinomas lec of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation. Anatomy, head and neck, sublingual gland statpearls ncbi. The most common locations of myoepithelioma of the head and neck are the parotid gland and the palate. Fineneedle aspiration biopsy fnab is a useful preoperative technique for the evaluation of patients with a salivary gland lesion1,2. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Pdf myoepithelioma of a minor salivary gland of the.
Primary lymphoepitheliomalike carcinoma of minor salivary gland. The cystic structures are filled with mucoid material and necrotic debris. It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors. Case epithelialmyoepithelial carcinoma of the report base.
In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors. In western countries, salivary gland lymphoepitheliallike carcinomas are uncommon and only 14 cases have been described so far. Pdf myoepithelioma of a minor salivary gland of the cheek. To our knowledge, there was only one lec arising from the minor salivary gland described in the englishlanguage literature. The major salivary glands consist of the parotid, submandibular, and sublingual glands. Characterisation of dog1 expression in salivary gland. Although parotid gland constitutes 60% of all pleomorphic adenomas, minor salivary glands constitute only 8% of them 1. Salivary gland tumors tehran university of medical sciences. Some studies have suggested that the dog1 protein may be essential for salivary gland secretion with a possible role in salivary gland tumourigenesis 5, 9. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology.
Original article histopathological study of salivary gland. Nonneoplastic disorders of the salivary glands are divided into the following groups. Doctors classify the subtype of salivary gland tumor by looking at tumor cells under a microscope, called a histologic evaluation. At the tata memorial hospital 3 in bombay the in cidence of salivary gland tumors is 0. Primary lymphoepitheliomalike carcinoma of minor salivary. Parotid gland is the most commonly affected among major salivary glands. Lymphoepithelial carcinoma is a rare salivary gland lesion.
Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. The majority of these neoplasms are benign and only 20% are malignant. They are seen as reddishyellow masses, which may be solid or a mixture of solid and cystic. Presence of a tumor mass on the face or in the mouth. Although surgery has been used for treatment of epithelialmyoepithelial carcinoma at all sites, the present case shows that chemotherapy and radiotherapy may be a viable option for treating epithelialmyoepithelial carcinoma of the base of tongue. The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts.
Most of these tumors are located on the parotid region. One duct is dilated and has an increased number of epithelial cells arrow. Classically, they are found in the parotid gland or palate. The annual incidence of salivary gland cancers ranges from 0. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the.
There is an increase in the number of ductal profiles within the gland. Salivary gland tumors represent 3% of all head and neck tumors. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. The parotid gland pg is mainly composed of serous acinisecreting. Minor salivary gland tumors msgts are infrequent, accounting for 1015% of all salivary neoplasms, and are fundamentally located in the palate 50%, lips 15%.
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